Author

M. V. Shirmanova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:imaging· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

E. A. Shirshin· 2 shared E. E. Nikonova· 2 shared L. E. Shimolina· 2 shared N. I. Ignatova· 2 shared A. A. Moshchenko· 1 shared A. D. Komarova· 1 shared A. E. Karnaeva· 1 shared A. M. Mozherov· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

E. A. Shirshin

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Author profile →

3 papers

Recent·Most cited

Metabolic heterogeneity of colorectal cancer as a prognostic factor: insights gained from fluorescence lifetime imaging

A. D. Komarova, S. D. Sinyushkina, I. D. Shchechkin, I. N. Druzhkova, S. A. Smirnova, V. M. Terekhov, A. M. Mozherov, N. I. Ignatova, E. E. Nikonova, E. A. Shirshin, L. E. Shimolina, S. V. Gamayunov, V. I. Shcheslavskiy, M. V. Shirmanova

This study uses fluorescence lifetime imaging to quantify metabolic heterogeneity in colorectal cancer, finding higher heterogeneity in patient tumors compared to cell lines and xenografts, with potential prognostic value.

bioRxiv · Jan 2, 2024Cancer Biology

Grubraw, a chemogenetic mitochondrial activator, reveals new mechanisms underlying the Warburg effect

E. S. Potekhina, D. Y. Bass, A. V. Ivanenko, A. A. Moshchenko, D. A. Korzhenevskiy, E. Shevchenko, A. E. Karnaeva, N. F. Zakirova, A. V. Ivanov, L. E. Shimolina, M. V. Shirmanova, O. V. Lyang, O. I. Patsap, O. M. Kudryashova, G. R. Gazizova, , V. Belousov

The paper introduces Grubraw, a chemogenetic tool that activates mitochondrial respiration in Warburg-type cancer cells, revealing that mitochondrial pyruvate export and reduced proliferation occur.

bioRxiv · Apr 18, 2023 · PreprintCancer Biology

Label-free sensing of cells with fluorescence lifetime imaging: the quest for metabolic heterogeneity

E. A. Shirshin, M. V. Shirmanova, A. V. Gayer, M. M. Lukina, E. E. Nikonova, B. P. Yakimov, G. S. Budylin, V. V. Dudenkova, N. I. Ignatova, D. V. Komarov, V. V. Yakovlev, W. Becker, E. V. Zagaynova, V. V. Shcheslavskiy, M. O. Scully

This study demonstrates a novel FLIM data analysis approach to better detect metabolic heterogeneity in cancer cells, validated through chemotherapy-treated cell imaging.

bioRxiv · Jan 12, 2022Cancer Biology