Unlocking DNA Damage Sensitivity of Cancer Cells: The Potential of Splicing Inhibitors
K. S. Anufrieva, M. M. Lukina, O. M. Ivanova, A. N. Kazakova, P. V. Shnaider, K. M. Klimina, V. A. Veselovsky, A. V. Luzhin, A. K. Velichko, O. L. Kantidze, E. N. Mochalova, M. P. Nikitin, A. V. Kashina, E. A. Vasilchikova, R. V. Deev, , V. O. Shender
This study shows splicing inhibitors induce DNA repair gene downregulation in cancer cells, creating a vulnerability that can be exploited by combining them with DNA-damaging agents.
bioRxiv · Oct 8, 2023 · PreprintCancer Biology