Cholesterol biosynthetic pathway induces cellular senescence through ERRa
D. V. Ziegler, M. Vernier, J. Czarnecka-Herok, C. Scholtes, C. Machon, J. Guitton, J. Rieusset, V. Giguere, N. Martin, D. Bernard
This study shows the mevalonate pathway promotes cellular senescence via ERRα, causing mitochondrial dysfunction, ROS, DNA damage, and p53-dependent senescence.
bioRxiv · Oct 20, 2021Cell Biology