Author

J. R. Grover

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

P. D. Uchil· 4 shared W. Mothes· 4 shared M. Lu· 3 shared S. Ding· 3 shared A. Finzi· 2 shared B. Zhang· 2 shared G. Beaudoin-Bussieres· 2 shared J. Prevost· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersMicrobiology

P. D. Uchil

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An intact amber-free HIV-1 system for in-virus protein bioorthogonal click labeling that delineates envelope conformational dynamics

Y. Ao, J. R. Grover, Y. Han, G. Zhong, W. Qin, D. Ghimire, M. A. Haque, R. Bhattacharjee, B. Zhang, J. Arthos, E. A. Lemke, P. D. Kwong, M. Lu

This paper develops an amber-free HIV-1 system for in-virus protein labeling, enabling smFRET analysis of Env conformational dynamics without disrupting structural integrity.

bioRxiv · Feb 28, 2023 · PreprintMicrobiology

Asymmetric HIV-1 envelope trimers bound to one and two CD4 molecules are intermediates during membrane binding

W. Li, E. Nand, Z. Qin, M. W. Grunst, J. R. Grover, J. W. Bess, J. D. Lifson, M. B. Zwick, H. D. Tagare, P. D. Uchil, W. Mothes

The paper uses cryo-ET to study HIV-1 Env-CD4 interactions on membranes, revealing asymmetric trimers bound to one or two CD4 molecules as intermediates in virus binding.

bioRxiv · Dec 23, 2022Microbiology

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

Y. Chen, J. Prevost, I. Ullah, H. Romero, V. Lisi, W. D. Tolbert, J. R. Grover, S. Ding, S. Y. Gong, G. Beaudoin-Bussieres, R. Gasser, M. Benlarbi, D. Vezina, S. P. Anand, D. Chatterjee, , A. Finzi

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

bioRxiv · Jul 27, 2022 · PreprintMicrobiology

CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter

S. A. Leonhardt, M. D. Purdy, J. R. Grover, Z. Yang, S. Poulos, W. E. McIntire, E. A. Tatham, S. Erramilli, K. Nosol, K. K. Lai, S. Ding, M. Lu, P. D. Uchil, A. D. Finzi, A. Rein, , M. Yeager

The paper shows SERINC3 has a structure similar to lipid transporters and demonstrates its lipid flipping activity, which correlates with reduced HIV-1 infectivity.

bioRxiv · Jul 6, 2022 · PreprintBiophysics

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles

M. Lu, P. D. Uchil, W. Li, D. Zheng, D. S. Terry, J. Gorman, W. Shi, B. Zhang, T. Zhou, S. Ding, R. Gasser, J. Prevost, G. Beaudoin-Bussieres, S. P. Anand, A. Laumaea, , W. Mothes

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

bioRxiv · Sep 10, 2020Microbiology