BET Bromodomain Proteins Regulate Transcriptional Reprogramming in Genetic Dilated Cardiomyopathy
A. Antolic, H. Wakimoto, Z. Jiao, J. M. Gorham, S. R. DePalma, D. A. Conner, D. Y. Lee, J. Qi, J. G. Seidman, J. E. Bradner, J. D. Brown, S. M. Haldar, C. E. Seidman, M. A. Burke
This study shows BET bromodomain proteins drive inflammatory gene networks in cardiac fibroblasts, contributing to genetic dilated cardiomyopathy, and that JQ1, a BET inhibitor, reduces disease progression.
bioRxiv · Feb 9, 2020Cell Biology