J. Jeong

A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.

Ultrasound programmable hydrogen-bonded organic frameworks for sono-chemogenetics

This paper introduces ultrasound programmable hydrogen-bonded organic frameworks (HOFs) for targeted drug release and neural circuit modulation in deep brain regions.

Effects of Alternative Splicing-Specific Knockdown of Tjp1 α+ by Rbm47 on Tight Junctions Assembly during Blastocyst Development

This study shows that selective knockdown of Tjp1 + via Rbm47 siRNA in mouse blastocysts does not impair blastocyst development or TJ permeability, indicating Tjp1 + is not essential for TJ assembly during early development.

DNA-Stimulated Liquid-Liquid Phase Separation by Eukaryotic Topoisomerase II Modulates Catalytic Function

This study shows that DNA-induced phase separation of eukaryotic type IIA topoisomerases switches their function from DNA unlinking to catenation.

Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

The paper shows that intracellular calcium, triggered by milk stasis, activates STAT3 via SOCS3 degradation and TFEB, leading to lysosome-dependent cell death during mammary gland involution.

Weak tension accelerates hybridization and dehybridization of short oligonucleotides

This study measures how weak tension affects DNA hybridization and dehybridization rates using a DNA bow assay and single-molecule FRET, finding increased rates with tension for various sequences.

Systems-wide Analysis Revealed Shared and Unique Responses to Moderate and Acute High Temperatures in the Green Alga Chlamydomonas reinhardtii

This study identifies shared and unique cellular responses to moderate and acute high temperatures in Chlamydomonas reinhardtii, revealing mechanisms for thermotolerance.

Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

Essential Role of Placenta Derived Interferon Stimulated Gene 20 Against ZIKA Virus Infection

This study identifies ISG20 as a key antiviral factor against Zika virus in trophoblast cells and demonstrates the therapeutic potential of recombinant ISG20-Fc protein.

Implantable photonic neural probes for light-sheet fluorescence brain imaging

The paper introduces implantable photonic neural probes that enable light-sheet fluorescence imaging in brain tissues without additional micro-optic components.

Ex vivo therapeutic base and prime editing using chemically derived hepatic progenitors in a mouse model of tyrosinemia type 1

This study corrects a disease-causing mutation in a mouse model of tyrosinemia type 1 using ex vivo base and prime editing with chemically derived hepatic progenitors, improving survival rates.

Ferroportin 3 is a dual-targeted mitochondrial/chloroplast iron exporter necessary for iron homeostasis in Arabidopsis

This study identifies FPN3 as a dual-targeted iron exporter in Arabidopsis mitochondria and chloroplasts, essential for iron homeostasis and growth under iron deficiency.

Gait analysis of healthy rhesus monkeys using a pressure-sensing walkway system

This study analyzed gait parameters of healthy rhesus monkeys using a pressure-sensing walkway, revealing forelimb dominance in weight distribution and symmetric gait patterns.

Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis

This study uses single-cell RNA sequencing to identify zone-specific transcriptomic changes in liver sinusoidal endothelial cells in cirrhosis, revealing Zone 3 LSECs as most susceptible to damage.

Multiplex generation, tracking, and functional screening of substitution mutants using a CRISPR/retron system

This paper develops a CRISPR/retron system for high-throughput generation and tracking of substitution mutations in E. coli, enabling genome-scale screening of chemical responses and fitness changes.

Chlamydomonas sp. UWO241 exhibits high cyclic electron flow and rewired metabolism under high salinity

This study investigates how Chlamydomonas sp. UWO241 maintains high cyclic electron flow and rewired metabolism under high salinity stress.

YAP nuclear translocation through dynein and acetylated microtubule controls fibroblast activation.

This study shows that YAP nuclear translocation via dynein and acetylated microtubules promotes myofibroblast differentiation in soft substrates, enhancing TGF-β1-induced Smad activity.

Associations between absolute neutrophil count and lymphocyte-predominant breast cancer

The paper investigates the association between absolute neutrophil count and lymphocyte-predominant breast cancer, finding lower ANC in LPBC patients.

Base-pair mismatch can destabilize small DNA loops through cooperative kinking

This study uses single-molecule FRET to show that base-pair mismatches in DNA loops reduce loop lifetime through cooperative kinking, despite lowering bending stress.

Determinants of cyclization-decyclization kinetics of short DNA with sticky ends

The paper measures cyclization and decyclization rates of short DNA with sticky ends using single-molecule FRET, finding length-dependent oscillations in decyclization rates and agreement with a three-state cyclization model.