Immunotherapy restores therapeutic efficacy of fecal microbiome transplants to treat Clostridioides difficile
Subham Mridha, Md Zahidul Alam, Joshua E. Denny, Ellie N Hulit, Jeffrey R. Maslanka, Nontokozo V. Mdluli, Minh Tran-Ha, Kevin S Mears, Daivon D Brown, Mohamad‐Gabriel Alameh, Michael C. Abt
This study shows that IL-10 signaling deficiency impairs FMT engraftment and C. difficile resolution, and that IL-10 immunotherapy can restore FMT efficacy in mice.
bioRxiv · Sep 23, 2026 · PreprintImmunology