Jeffrey R. Maslanka

Immunotherapy restores therapeutic efficacy of fecal microbiome transplants to treat Clostridioides difficile

This study shows that IL-10 signaling deficiency impairs FMT engraftment and C. difficile resolution, and that IL-10 immunotherapy can restore FMT efficacy in mice.

Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4+ T cell responses

The paper develops an MHC-II tetramer to track TcdB-specific CD4+ T cells in mice, validating its use in identifying Tfh cells and generating toxin-specific T cells.

Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells

This study shows Notch2 signaling enhances TLR3 and TLR4 responsiveness in MZ B cells, promoting immune responses to viral and bacterial pathogens.

Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function

This study shows that co-immunizing with adenosine deaminase and a DNA vaccine improves T follicular helper cell function and antibody quality in aged mice, enhancing protection against C. difficile infection.

Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity

This study shows that C. difficile toxins A and B inhibit their own antigen-specific immune responses via glucosyltransferase activity, contributing to recurrent infections.