Author

Joshua E. Denny

University of PennsylvaniaORCID 0000-0003-2004-5030Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ellie N Hulit· 2 shared Jeffrey R. MaslankaiD· 2 shared Michael C. AbtiD· 2 shared Mohamad‐Gabriel AlamehiD· 2 shared Nontokozo V. Mdluli· 2 shared Chenjie ZengiD· 1 shared Daivon D Brown· 1 shared Dana Borden LacyiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Ellie N Hulit

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Immunotherapy restores therapeutic efficacy of fecal microbiome transplants to treat Clostridioides difficile

Subham Mridha, Md Zahidul Alam, Joshua E. Denny, Ellie N Hulit, Jeffrey R. Maslanka, Nontokozo V. Mdluli, Minh Tran-Ha, Kevin S Mears, Daivon D Brown, Mohamad‐Gabriel Alameh, Michael C. Abt

This study shows that IL-10 signaling deficiency impairs FMT engraftment and C. difficile resolution, and that IL-10 immunotherapy can restore FMT efficacy in mice.

bioRxiv · Sep 23, 2026 · PreprintImmunology

Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity

Jeffrey R. Maslanka, Jennifer Londregan, Joshua E. Denny, Ellie N Hulit, Nontokozo V. Mdluli, F. Christopher Peritore‐Galve, Md. Zahidul Alam, Mohamad‐Gabriel Alameh, Dana Borden Lacy, Joseph P. Zackular, Michael C. Abt

This study shows that C. difficile toxins A and B inhibit their own antigen-specific immune responses via glucosyltransferase activity, contributing to recurrent infections.

Mucosal Immunology · Aug 18, 2025Peer-reviewedImmunology

Replicating the Association of Variants in BSN and APBA1 with Obesity in Diverse Populations

Jamie R. Robinson, Joshua C. Denny, Chenjie Zeng

This study replicates and expands findings from Zhao et al. by showing that pLoF variants in BSN and APBA1 are strongly associated with BMI in diverse populations, particularly European ancestry, and uncover novel phenotypic associations.

medRxiv · Aug 21, 2024 · PreprintGenetic & Genomic Medicine