Michael C. Abt

This study shows that IL-10 signaling deficiency impairs FMT engraftment and C. difficile resolution, and that IL-10 immunotherapy can restore FMT efficacy in mice.

The paper develops an MHC-II tetramer to track TcdB-specific CD4+ T cells in mice, validating its use in identifying Tfh cells and generating toxin-specific T cells.

This study shows that co-immunizing with adenosine deaminase and a DNA vaccine improves T follicular helper cell function and antibody quality in aged mice, enhancing protection against C. difficile infection.

The paper investigates how IL-10 signaling interacts with circadian rhythms to influence the host response to influenza infection, finding that blocking IL-10 signaling abolishes time-of-day-specific protection.

This study shows that C. difficile toxins A and B inhibit their own antigen-specific immune responses via glucosyltransferase activity, contributing to recurrent infections.