NKTR-255, a polymer-conjugated IL-15, synergizes with CAR-T cell therapy to activate endogenous anti-tumor immunity and improve tumor control
W. Sam Nutt, Mitchell G. Kluesner, Emma Bingham, Ekram A. Gad, Dani Miller, Victor Zepeda, Andrew J. Snyder, Sydney A. Marsh, Shannon M. Liudahl, Mari Hoffman, Lillian LeBlanc, Madeleine E. Volfbeyn, Sarah M. Garrison, Megha Sarvothama, Kevin C. Barry, , Shivani Srivastava
This study shows that combining NKTR-255 with CAR-T therapy enhances tumor control by boosting CAR-T function and endogenous anti-tumor immunity in solid tumors.
bioRxiv · Dec 15, 2025 · PreprintImmunology