Author

Kevin C. Barry

Fred Hutch Cancer CenterORCID 0000-0003-1064-5964Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Adrianne Wallace-PovirkiD· 1 shared Aidan SchutteriD· 1 shared Alexander E. Orellana· 1 shared Amy D. WillisiD· 1 shared Andrew J. SnyderiD· 1 shared Camilla Rydberg MillrudiD· 1 shared Caroline Kasman· 1 shared Dani Miller· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

Adrianne Wallace-PovirkORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 6, 2026

HMGA2 Expression in Pancreatic Ductal Adenocarcinoma Controls Tumor Microenvironment and Immunosuppression via IL1α

Naomi Yamamoto, Stephanie Dobersch, Tess M. Robertson…·Sita Kugel

This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.

DOI 10.64898/2026.10.02.754697

humanbulk RNA-seq

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ImmunologybioRxivPreprintDec 15, 2025

NKTR-255, a polymer-conjugated IL-15, synergizes with CAR-T cell therapy to activate endogenous anti-tumor immunity and improve tumor control

W. Sam Nutt, Mitchell G. Kluesner, Emma Bingham…·Shivani Srivastava

This study shows that combining NKTR-255 with CAR-T therapy enhances tumor control by boosting CAR-T function and endogenous anti-tumor immunity in solid tumors.

1 citation

mouseexperimental assay

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BioinformaticsGenome biologyPeer-reviewedMay 5, 2021

Gene-level metagenomics identifies genome islands associated with immunotherapy response

Samuel S. Minot, Kevin C. Barry, Caroline Kasman…·Amy D. Willis

The paper introduces a tool for gene-level metagenomic analysis to identify genomic islands linked to immunotherapy response in microbiome data.

21 citations

humanmetagenomics

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