Author

Ekram A. Gad

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Andrew J. SnyderiD· 2 shared Emma BinghamiD· 2 shared Megha Sarvothama· 2 shared Mitchell G. KluesneriD· 2 shared Sarah M. GarrisoniD· 2 shared Shivani SrivastavaiD· 2 shared Sydney A. MarshiD· 2 shared Victor ZepedaiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Andrew J. SnyderORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade

Andrew J. Snyder, Sarah M. Garrison, Mitchell G. Kluesner, W. Sam Nutt, Carolyn Shasha, T. T. Giang Ho, Sydney A. Marsh, Miles Hamilton Linde, Feinan Wu, Lauren K. Meyer, Amelia R. Wilhelm, Sergio Ortiz‐Espinosa, Victor Zepeda, Emma Bingham, Haleema S. Malik, , Shivani Srivastava

This study shows that overexpressing c-Jun in CAR-T cells enhances their ability to maintain PD-1+Tcf1+ stem-like cells in tumors and improves response to PD-L1 blockade.

Science Immunology · Mar 6, 2026Peer-reviewedImmunology

NKTR-255, a polymer-conjugated IL-15, synergizes with CAR-T cell therapy to activate endogenous anti-tumor immunity and improve tumor control

W. Sam Nutt, Mitchell G. Kluesner, Emma Bingham, Ekram A. Gad, Dani Miller, Victor Zepeda, Andrew J. Snyder, Sydney A. Marsh, Shannon M. Liudahl, Mari Hoffman, Lillian LeBlanc, Madeleine E. Volfbeyn, Sarah M. Garrison, Megha Sarvothama, Kevin C. Barry, , Shivani Srivastava

This study shows that combining NKTR-255 with CAR-T therapy enhances tumor control by boosting CAR-T function and endogenous anti-tumor immunity in solid tumors.

bioRxiv · Dec 15, 2025 · PreprintImmunology