Author

Daniel A. Engel

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

Tsuyoshi Miyake· 2 shared Abigail L. Whitford· 1 shared Aleksandra W. BabnisiD· 1 shared Anna Ruth CliffeiD· 1 shared Erin A. WeddleiD· 1 shared Hervé AgaisseiD· 1 shared Lauren K. YumiD· 1 shared M. E. FloresiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Tsuyoshi Miyake

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation

Steven J. Rolland, Zachary J Lifschin, Erin A. Weddle, Lauren K. Yum, Tsuyoshi Miyake, Daniel A. Engel, Hervé Agaisse

This study identifies PIK3C3 as essential for Shigella flexneri cell-to-cell spread by facilitating vacuole formation through PtdIns(3)P accumulation and Dynamin 2 recruitment.

PLoS Pathogens · May 16, 2025Peer-reviewedMicrobiology

Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent Infection

Patryk A. Krakowiak, M. E. Flores, Sean R. Cuddy, Abigail L. Whitford, Sara Anna Dochnal, Aleksandra W. Babnis, Tsuyoshi Miyake, Marco Tigano, Daniel A. Engel, Anna Ruth Cliffe

This study shows HSV-1 UL12.5 promotes reactivation by inducing mitochondrial nucleic acid sensing, which activates innate immune pathways and supports lytic gene expression during latency exit.

Proceedings of the National Academy of Sciences · Jan 24, 2025Peer-reviewedMicrobiology