Author

Patryk A. Krakowiak

University of VirginiaORCID 0000-0002-5120-9811Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Abigail L. Whitford· 2 shared Anna Ruth CliffeiD· 2 shared Sara Anna DochnaliD· 2 shared Aleksandra W. BabnisiD· 1 shared Daniel A. Engel· 1 shared M. E. FloresiD· 1 shared Marco TiganoiD· 1 shared Sean R. CuddyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

Abigail L. Whitford

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2 papers

Recent·Most cited

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedJan 24, 2025

Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent Infection

Patryk A. Krakowiak, M. E. Flores, Sean R. Cuddy…·Anna Ruth Cliffe

This study shows HSV-1 UL12.5 promotes reactivation by inducing mitochondrial nucleic acid sensing, which activates innate immune pathways and supports lytic gene expression during latency exit.

9 citationstop 3%

humanexperimental assay

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MicrobiologyMicrobiology SpectrumPeer-reviewedNov 11, 2024

Physiological oxygen concentration during sympathetic primary neuron culture improves neuronal health and reduces HSV-1 reactivation

Sara Anna Dochnal, Patryk A. Krakowiak, Abigail L. Whitford, Anna Ruth Cliffe

This study shows that culturing primary neurons at physiological oxygen levels (5%) improves neuronal health and reduces HSV-1 reactivation without affecting latency establishment.

4 citations

mousebulk RNA-seq

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