Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes
Matthew Milton, Sahar H. Farag, Diana J. Garay‐Baquero, Jennie Gullick, Kinga Niedobecka, Daniel Burns, Rita Szoke‐Kovacs, Patrick Trimby-Smith, Alex Look, Richard J Stopforth, Marco Lepore, David K. Cole, Laura Denney, Andrew White, S. Sharpe, , Salah Mansour
This study shows CD1c-autoreactive T-cells recognize Mtb-infected APCs, exhibit cytotoxicity, and reduce Mtb burden through CD1c-dependent mechanisms.
bioRxiv · Jun 23, 2026Immunology