Author

David K. Cole

Immunocore (United Kingdom)ORCID 0000-0003-0028-9396Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Alasdair J. LeslieiD· 1 shared Alex LookiD· 1 shared Ana Mafalda SantosiD· 1 shared Andrés F. VallejoiD· 1 shared Andrew WhiteiD· 1 shared Ben de WetiD· 1 shared Bin FuiD· 1 shared Bing LiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Alasdair J. LeslieORCID

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2 papers

Recent·Most cited

ImmunologybioRxivJun 23, 2026

Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes

Matthew Milton, Sahar H. Farag, Diana J. Garay‐Baquero…·Salah Mansour

This study shows CD1c-autoreactive T-cells recognize Mtb-infected APCs, exhibit cytotoxicity, and reduce Mtb burden through CD1c-dependent mechanisms.

DOI 10.7554/elife.110341

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintAug 29, 2025

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

Mateusz Kotowski, Daniel F. Heraghty, Markus Körbel…·Simon J. Davis

The paper shows that T-cell activation is initiated by partial CD45 exclusion at sub-micron contacts, leading to strong activation and cytotoxicity through small signaling changes.

3 citations

humanflow cytometry

𝕏 PostBluesky