Author

Kinga Niedobecka

National Institute for Health and Care Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:non-human primate· 1 Assay:structural biology· 1

Frequent Co-Authors

Alex LookiD· 2 shared Andrew WhiteiD· 2 shared Paul T. ElkingtoniD· 2 shared Rita Szoke‐KovacsiD· 2 shared Salah MansouriD· 2 shared Alasdair J. LeslieiD· 1 shared Ali RoghanianiD· 1 shared Andrés F. VallejoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Alex LookORCID

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Author profile →

2 papers

Recent·Most cited

Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes

Matthew Milton, Sahar H. Farag, Diana J. Garay‐Baquero, Jennie Gullick, Kinga Niedobecka, Daniel Burns, Rita Szoke‐Kovacs, Patrick Trimby-Smith, Alex Look, Richard J Stopforth, Marco Lepore, David K. Cole, Laura Denney, Andrew White, S. Sharpe, , Salah Mansour

This study shows CD1c-autoreactive T-cells recognize Mtb-infected APCs, exhibit cytotoxicity, and reduce Mtb burden through CD1c-dependent mechanisms.

bioRxiv · Jun 23, 2026Immunology

Ligand-responsive groove remodelling in human and macaque CD1d reveals a conserved MHC-like gating mechanism

Daniel J. Burns, Alex Look, Steven Turner, Martin Maly, Oliver J. Melling, Kinga Niedobecka, Rita Szoke‐Kovacs, Hatice Nurdan Aksoy Kilinc, Richard J. Suckling, Andrew Chancellor, Mariolina Salio, Andrew White, Sally A. Sharpe, Ali Roghanian, Bruno Linclau, , Salah Mansour

This study determines the crystal structures of human and macaque CD1d bound to -GalCer, revealing conserved ligand-responsive conformational flexibility at Phe84 that modulates antigen presentation.

bioRxiv · Dec 25, 2025 · PreprintImmunology