Ian R. Lanza

Lysosomal lipid metabolism promotes tumor cell invasion through local energetics and membrane lipid remodeling

This study identifies lysosomal lipid metabolism as a driver of pancreatic cancer cell invasion through local energy production and membrane remodeling.

Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats

The paper identifies tissue-specific transcriptional regulatory programs in rats undergoing endurance exercise training by integrating chromatin accessibility, DNA methylation, and gene expression data.

Multilevel impairment of mitochondrial respiration with sex-specific signatures in inclusion body myositis

This study profiles mitochondrial respiration in IBM muscle tissue, identifying sex-specific impairments in respiration and OXPHOS complexes, along with correlations with disease severity.

Mitochondria-centered metabolomic map of inclusion body myositis: sex-specific alterations in central carbon metabolism

This study identifies sex-specific metabolic alterations in IBM muscle tissue, showing changes in central carbon metabolism and correlations with clinical parameters.

The mitochondrial multi-omic response to exercise training across tissues

This study maps multi-omic mitochondrial changes across 19 tissues in rats after endurance exercise training, identifying tissue-specific adaptations and disease-related hubs.

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.