Jesús Gil

This study shows that standard therapies for paediatric BRAF-V600E glioma induce senescence, which can be targeted by BCL-xL inhibitors to prevent tumour regrowth.

This study shows that TERT expression in adipose tissue reduces inflammation and improves metabolism in obesity by altering macrophage states and stem cell-macrophage communication.

The paper identifies mechanisms that prevent innate immune activation by TE-derived cytosolic DNA, preserving pluripotency in ESCs.

This study shows that TERT reduces obesity-induced metabolic disorders by promoting adipose stem cell expansion and differentiation, and remodeling macrophages in adipose tissue.

This study shows that combining radiation with Bcl-xL inhibition reduces tumor growth in preclinical models of H3K27M-altered diffuse midline glioma.

The paper establishes international consensus criteria to classify ageing-related pathologies, diseases, and syndromes based on age progression, functional decline, and human evidence.

This study shows that inhibiting IL11 improves healthspan in aged mice by reversing metabolic dysfunction, sarcopenia, and frailty.

The paper analyzes cysteine accessibility in proteomic datasets to identify ligandable residues and proposes a framework for benchmarking cysteine profiling approaches.

The paper identifies AP-1's role in shaping the epigenetic landscape of senescent cells and presents a hierarchical TF network model for senescence reprogramming.