Image-based screens identify regulators of endogenous Dvl2 biomolecular condensates
Antonia Schubert, Florian Heigwer, Christian Scheeder, Oksana Voloshanenko, Dominique Kranz, Franziska Ragaller, Nadine Winkler, Thilo Miersch, Barbara A. Schmitt, Melanie Kuhse, Daniel Gimenes, Diana Ordoñez‐Rueda, Jennifer Schwarz, Frank Stein, Dirk Jäger, , Michael Boutros
The paper identifies regulators of Dvl2 biomolecular condensates using image-based screens and phosphoproteomics, finding CK1δ/ε inhibition blocks condensate formation and modulates Wnt signaling.
bioRxiv · Jan 11, 2025 · PreprintCell Biology