Direct capture of CRISPR guides enables scalable, multiplexed, and multi-omic Perturb-seq
Joseph M. Replogle, Thomas M. Norman, Albert Xu, Jeffrey A. Hussmann, Jin Chen, J. Zachery Cogan, Elliott J. Meer, Jessica M. Terry, Daniel P. Riordan, Niranjan Srinivas, Ian T. Fiddes, Joseph G. Arthur, Luigi J. Alvarado, Katherine A. Pfeiffer, Tarjei Sigurd Mikkelsen, , Britt Adamson
This paper introduces a method to directly capture CRISPR guides in single-cell RNA-sequencing libraries, enhancing Perturb-seq scalability and enabling multi-omic measurements.
Nature Biotechnology · Mar 30, 2020Peer-reviewedGenomics