Jin Chen

This study identifies ARMC1 as a regulator of mitochondrial fatty acid oxidation through its interaction with MTCH2, showing that this interaction suppresses FAO during starvation.

This study investigates how a genetic variant disrupts proteostasis networks, leading to cognitive dysfunction, and identifies a viral protein that can reverse these deficits.

This study identifies CD47 as a more effective macrophage immune checkpoint than CD24 in cancer and develops bispecific antibodies to enhance macrophage-mediated tumor killing.

This study maps RNA translation dynamics in the human brain using ribosome profiling, identifying thousands of novel translation events and brain-specific microproteins linked to schizophrenia.

This paper outlines a community-driven initiative to create a consolidated catalog of human Ribo-seq ORFs, addressing the lack of standardized annotation for these features.

The paper develops improved machine learning models to predict translation initiation sites in neurologic diseases with expanded repeats, achieving higher accuracy than previous methods.

This paper introduces a method to directly capture CRISPR guides in single-cell RNA-sequencing libraries, enhancing Perturb-seq scalability and enabling multi-omic measurements.