GeneticsMolecular CellPeer-reviewed
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control
Kelsey L. Hickey, Kimberley Dickson, J. Zachery Cogan…·Kamena K. Kostova
The paper identifies GIGYF2 and 4EHP as translation inhibitors that suppress re-initiation of defective mRNAs, aiding ribosome-associated quality control and preventing toxic protein accumulation.