Metabolic modeling reveals the aging-associated decline of host-microbiome metabolic interactions in mice
Lena Best, Thomas Dost, Daniela Esser, Stefano Flor, Andy Mercado Gamarra, Madlen Haase, A. Samer Kadibalban, Γεώργιος Μαρίνος, Alesia Walker, Johannes Zimmermann, Rowena Simon, Silvio Schmidt, Jan Taubenheim, Sven Künzel, Robert Häsler, , Christoph Kaleta
This study uses multi-omics and metabolic modeling in mice to show that aging reduces host-microbiome metabolic interactions, affecting key host pathways involved in intestinal barrier function and homeostasis.
Nature Microbiology · Mar 26, 2025Peer-reviewedSystems Biology