Lena Best

This study identifies nonlinear gene-expression trajectories in the aging male mouse colon, revealing midlife transitions and a transcriptomic clock based on three genes.

The paper integrates multi-omics data from mice to identify molecular features linked to aging-related cognitive decline, highlighting systemic inflammation and microbiome-driven gut-brain axis dysfunction.

This study uses multi-omics and metabolic modeling in mice to show that aging reduces host-microbiome metabolic interactions, affecting key host pathways involved in intestinal barrier function and homeostasis.

This study shows that deleting HKDC1 in intestinal epithelial cells reduces tumor growth and protects against colorectal cancer in mice by impairing mitochondrial function and cell proliferation.