CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer
Alex C.Y. Chen, Keely Y. Ji, Cansu Yerinde, Nelson H. Knudsen, Kevin Bi, Shumeng Hao, Vasyl Zhabotynsky, Daniela Martinez, Thomas James LaSalle, Kazuhiro Taguchi, Katherine H. Xu, Elizabeth M. Seider, Marc A. Schwartz, Maria Zschummel, Linda T. Nieman, , Debattama R. Sen
This study identifies Dusp5 and Zfp219 as key regulators of age-related T cell dysfunction using CRISPR screens and shows their potential as therapeutic targets.
Cell · Jul 29, 2026Peer-reviewedImmunology