Maria Zschummel

This study identifies sex-biased mechanisms of immune aging in males, showing lymph node contraction reduces naive CD8 T cell availability and compromises cancer antigen recognition, with potential therapeutic interventions.

This study identifies Dusp5 and Zfp219 as key regulators of age-related T cell dysfunction using CRISPR screens and shows their potential as therapeutic targets.

The paper uses in vivo CRISPR screens to identify genes affecting CAR T cell persistence and function in multiple myeloma, finding CDKN1B as a key regulator of late-stage CAR T cell fitness.

This study shows that varying levels of oncogenic KRAS drive different cell states and metastatic progression in lung adenocarcinoma, with implications for treatment.