PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes
Brandon T Paradoski, Sen Hou, Edgard M. Mejia, Folayemi Olayinka‐Adefemi, Danielle Fowke, Grant Michael Hatch, Ayesha Saleem, Versha Banerji, Nissim Hay, Hu Zeng, Aaron J. Marshall
This study shows that PI3K-dependent upregulation of hexokinase 2 (HK2) controls glucose metabolism and immune functions in B cells, with HK2-deficient B cells showing impaired metabolic and functional responses.
iScience · Sep 13, 2024Peer-reviewedImmunology