Author

Grant Michael Hatch

Children's Hospital Research Institute of ManitobaORCID 0000-0002-1568-6071Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Aaron J. MarshalliD· 1 shared Abhay SrivastavaiD· 1 shared Amir Barzegar BehrooziD· 1 shared Amir RavandiiD· 1 shared Ayesha SaleemiD· 1 shared Bhavya Bhushan· 1 shared Brandon T ParadoskiiD· 1 shared Christopher D. PascoeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

Aaron J. MarshallORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Autophagy Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma

Shahla Shojaei, Amir Barzegar Behrooz, Kianoosh Naghibzadeh, João Luiz Martins Basso, Javad Alizadeh, Tania Dehesh, Roham Saberi, Bhavya Bhushan, Mehdi Eshraghi, Simone CDS Rosa, Courtney Jessica Clark, Mateusz M. Tomczyk, Laura Cole, Grant Michael Hatch, Vernon Wayne Dolinsky, , Saeid Ghavami

This study shows that autophagy and cholesterol metabolism are remodeled in glioma progression and TMZ resistance, with impaired autophagy linked to reduced cholesterol synthesis and altered lipid profiles.

bioRxiv · Jan 20, 2026 · PreprintCancer Biology

PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes

Brandon T Paradoski, Sen Hou, Edgard M. Mejia, Folayemi Olayinka‐Adefemi, Danielle Fowke, Grant Michael Hatch, Ayesha Saleem, Versha Banerji, Nissim Hay, Hu Zeng, Aaron J. Marshall

This study shows that PI3K-dependent upregulation of hexokinase 2 (HK2) controls glucose metabolism and immune functions in B cells, with HK2-deficient B cells showing impaired metabolic and functional responses.

iScience · Sep 13, 2024Peer-reviewedImmunology