Cell fate coordinates mechano-osmotic forces in intestinal crypt morphogenesis
Qiutan Yang, Shi-Lei Xue, Chii Jou Chan, Markus Rempfler, Dario Vischi, Francisca G. Maurer, Takashi Hiiragi, Édouard Hannezo, Prisca Liberali
The paper shows how cell fate-specific changes in osmotic and actomyosin forces coordinate robust organoid morphogenesis through lumen volume reduction and mechanical tension.
Nature Cell Biology · Jun 21, 2021Peer-reviewedDevelopmental Biology