Author

Shi-Lei Xue

Institute of Science and Technology AustriaORCID 0000-0002-3483-1852Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Édouard HannezoiD· 2 shared Alexander K. WinkeliD· 1 shared Chii Jou ChaniD· 1 shared Dario Vischi· 1 shared Denis KrndijaiD· 1 shared Dhriti SaumyaiD· 1 shared Étienne BuscailiD· 1 shared Fengzhu XiongiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersDevelopmental Biology

Édouard HannezoORCID

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3 papers

Recent·Most cited

Goblet cells mechanically breach the epithelial barrier in gut homeostasis

Justine Creff, Yuan He, Sandra Bernat-Fabre, Étienne Buscail, Salomé Neuvendel, Vishnu Krishnakumar, Dhriti Saumya, Laurent Malaquin, Thomas Mangeat, Shi-Lei Xue, Denis Krndija

This study shows that goblet cells create tight junction fractures between enterocytes, increasing gut permeability under homeostatic conditions and during hypertrophy.

DOAJ (DOAJ: Directory of Open Access Journals) · Jul 25, 2026Peer-reviewedCell Biology

Differential tissue deformability underlies shape divergence of the embryonic brain and spinal cord under fluid pressure

Susannah B. P. McLaren, Shi-Lei Xue, Siyuan Ding, Alexander K. Winkel, Oscar Baldwin, Shreya Dwarakacherla, Kristian Franze, Édouard Hannezo, Fengzhu Xiong

Developmental Cell · May 9, 2025Peer-reviewedDevelopmental Biology

Cell fate coordinates mechano-osmotic forces in intestinal crypt morphogenesis

Qiutan Yang, Shi-Lei Xue, Chii Jou Chan, Markus Rempfler, Dario Vischi, Francisca G. Maurer, Takashi Hiiragi, Édouard Hannezo, Prisca Liberali

The paper shows how cell fate-specific changes in osmotic and actomyosin forces coordinate robust organoid morphogenesis through lumen volume reduction and mechanical tension.

Nature Cell Biology · Jun 21, 2021Peer-reviewedDevelopmental Biology