Takashi Hiiragi

This study identifies how tissue boundaries guide cell orientation and lumen formation during mouse epiblast maturation.

The paper shows apical polarity in PrE cells drives robust tissue patterning in blastocysts by guiding migration and breaking symmetry.

The paper shows that stochastic division timing and cell mechanics contribute to robust embryo patterning and morphogenesis in mammals.

This study develops an engineered uterus-like microenvironment to study mouse embryo implantation, revealing coordination between trophoblast migration and embryo growth.

The paper shows how muscular hydraulic behavior in Nematostella vectensis drives larva-polyp morphogenesis through antagonistic muscle pressures.

This paper develops an ex vivo culture system to study mouse peri-implantation development, revealing a mechano-chemical interplay between extra-embryonic and embryonic tissues.

The paper shows that ECM-integrin adhesion enables cells to sense their position and specify ICM fate in early mouse embryos.

The paper shows how cell fate-specific changes in osmotic and actomyosin forces coordinate robust organoid morphogenesis through lumen volume reduction and mechanical tension.

This study shows that lumen expansion in mouse blastocysts is critical for epiblast and primitive endoderm fate specification and spatial segregation.

This study investigates how lumenal pressure and tissue mechanics regulate embryonic size and cell fate during mouse blastocyst development.