Lack of functional caveolae in Cav3 mutated human dystrophic myotubes results in deficient mechanoprotection and IL6/STAT3 mechanosignaling.
Melissa Dewulf, Darius Köster, Bidisha Sinha, Christine Viaris de Lesegno, Valérie Chambon, Anne Bigot, Nicolas Tardif, Ludger Johannes, Pierre Nassoy, Gillian Butler-Browne, Christophe Lamaze, Cedric M. Blouin
This study shows that Cav3 mutations in human dystrophic myotubes impair caveolae function, leading to defective mechanoprotection and aberrant IL6/STAT3 signaling.
bioRxiv · Mar 20, 2018 · PreprintCell Biology