Ludger Johannes

Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

This paper shows that EndoA3-mediated CIE and retrograde transport in cancer cells affect immune synapse organization and CD8 T cell responses by redistributing ICAM1 and ALCAM.

Targeting GL-Lect driven endocytosis to suppress cell plasticity in breast cancer

This study identifies GL-Lect driven endocytosis as a driver of metastatic plasticity in breast cancer and shows pharmacologic inhibition can suppress invasive phenotypes.

Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A

This study identifies Galectin-3 as a novel ligand for GPRC5A, demonstrating its role in mediating endocytosis of the orphan GPCR in colorectal cancer cells.

Lack of functional caveolae in Cav3 mutated human dystrophic myotubes results in deficient mechanoprotection and IL6/STAT3 mechanosignaling.

This study shows that Cav3 mutations in human dystrophic myotubes impair caveolae function, leading to defective mechanoprotection and aberrant IL6/STAT3 signaling.