Christophe Lamaze

The paper investigates how mechanical stress affects caveolae mechanics, leading to the release of caveolin-1 scaffolds and modulation of signaling pathways like JAK1, eNOS, PTEN, and PTP1B.

This paper presents a thermodynamic model showing how caveolae release components under tension, with EHD2 rings enabling a switch-like response to tension variations.

The paper shows that palmitoylated caveolin-1 facilitates endosome sorting of complex sphingolipids to the plasma membrane, independent of caveolae.

This study shows mechanical stress increases EV release from cancer cells via caveolin-1, leading to more tumorigenic EVs that promote metastasis.

This paper shows that AXL inhibits cholesterol mobilization in dendritic cells, which is necessary for their maturation and immunogenic response to cancer.

This study identifies STAM interaction with Hrs as critical for IFN-α-induced JAK/STAT activation at the early endosome, revealing endosomal sorting's role in differential signaling.

This study shows that Cav3 mutations in human dystrophic myotubes impair caveolae function, leading to defective mechanoprotection and aberrant IL6/STAT3 signaling.