Beyond Tumors: Reduced survival linked to pathogenic PIK3CA and TP53 post-zygotic variants in the uninvolved breast tissue of recurrent cancer patients
Maria Andreou, Katarzyna Chojnowska, Natalia H. Filipowicz, Monika Horbacz, Piotr Madanecki, Katarzyna Duzowska, Urszula Ławrynowicz, Hanna Davies, Bożena Bruhn‐Olszewska, Mikołaj Koszyński, Kinga Drężek-Chyła, Maciej Jaśkiewicz, Marcin Jąkalski, Anna Kostecka, Marta Drzewiecka, , Arkadiusz Piotrowski
The paper identifies pathogenic post-zygotic variants in normal breast tissue of poor-prognosis cancer patients, linking them to reduced survival and disease recurrence.
medRxiv · Oct 4, 2024 · PreprintGenetic & Genomic Medicine