Jakub Mieczkowski

α-Synuclein impairs mitochondrial function and alters cryptochrome regulation in the substantia nigra

This study shows that α-synuclein accumulation in dopaminergic neurons leads to mitochondrial dysfunction and changes in circadian gene expression, contributing to neuronal damage in Parkinson's disease.

Spatial Transcriptomics of TNBC tumours and corresponding lymph node metastasis reveals immune hubs driven by TNF/NF-κB signalling of TMSB4X and CD74 expressing cells.

The paper uses spatial transcriptomics to identify immune hubs in TNBC lymph node metastases driven by TMSB4X and CD74, revealing spatially expanded inflammatory networks and myeloid-endothelial signaling.

Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs

This study shows hypoxia alters myeloid cell functions in glioblastoma by changing gene expression and chromatin accessibility, affecting immune cell markers and transcription factor regulation.

Beyond Tumors: Reduced survival linked to pathogenic PIK3CA and TP53 post-zygotic variants in the uninvolved breast tissue of recurrent cancer patients

The paper identifies pathogenic post-zygotic variants in normal breast tissue of poor-prognosis cancer patients, linking them to reduced survival and disease recurrence.

p53 Regulates Nuclear Architecture to Reduce Carcinogen Sensitivity and Mutagenic Potential

The paper shows p53 maintains nuclear architecture to reduce carcinogen sensitivity and mutagenic potential by altering chromatin structure and UV lesion abundance.

Prelude to Malignancy: A Gene Expression Signature in Normal Mammary Gland from Breast Cancer Patients Suggests Pre-tumorous Alterations and Is Associated with Adverse Outcomes

Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases

The paper investigates LOY in TME leukocytes, finding higher LOY frequency in Tregs and its association with immune checkpoint receptor expression.

Loss of Y is associated with multi-omic changes in immune cells from Alzheimer's disease patients

The paper identifies multi-omic changes in immune cells from Alzheimer's disease patients with loss of Y, linking LOY to epigenetic and gene expression alterations.

Size matters - the impact of nucleus size on results from spatial transcriptomics

This study investigates how nucleus size affects spatial transcriptomics results and introduces CSDI to improve accuracy in analyzing consecutive tissue slices.