Urszula Ławrynowicz

This study shows that α-synuclein accumulation in dopaminergic neurons leads to mitochondrial dysfunction and changes in circadian gene expression, contributing to neuronal damage in Parkinson's disease.

The paper uses spatial transcriptomics to identify immune hubs in TNBC lymph node metastases driven by TMSB4X and CD74, revealing spatially expanded inflammatory networks and myeloid-endothelial signaling.

The paper identifies pathogenic post-zygotic variants in normal breast tissue of poor-prognosis cancer patients, linking them to reduced survival and disease recurrence.