Author

Kinga Drężek-Chyła

Gdańsk Medical UniversityORCID 0009-0007-1008-7145Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Assay:whole-exome sequencing· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jan Piotr DumanskiiD· 4 shared Natalia H. FilipowicziD· 4 shared Arkadiusz PiotrowskiiD· 3 shared Bożena Bruhn‐OlszewskaiD· 3 shared Hanna DaviesiD· 3 shared Monika HorbacziD· 3 shared Anna KosteckaiD· 2 shared Edyta Rychlicka-BuniowskaiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Jan Piotr DumanskiORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintJun 5, 2025

Loss of Y chromosome in Alzheimer disease patients co-occurs with clonal hematopoiesis defined by post-zygotic point mutations outside canonical CHIP driver genes

Edyta Rychlicka-Buniowska, Daniil Sarkisyan, Monika Horbacz…·Jan Piotr Dumanski

The paper investigates the relationship between loss of Y chromosome (LOY) and clonal hematopoiesis in Alzheimer's disease patients, finding that LOY drives myeloid clones which may accumulate additional mutations.

1 citation

humanwhole-exome sequencing

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Cancer BiologybioRxivPreprintMar 9, 2025

The effect of cold ischemia time on hypoxia, EMT, and apoptosis pathways in normal colon mucosa

Katarzyna Duzowska, Mikołaj Opiełka, Kinga Drężek-Chyła…·Natalia H. Filipowicz

This study evaluates how cold ischemia time affects gene expression in normal colon mucosa, identifying transcriptomic changes in hypoxia, EMT, and apoptosis pathways that may mimic malignancy.

DOI 10.1101/2025.03.09.642255

humanbulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintOct 4, 2024

Beyond Tumors: Reduced survival linked to pathogenic PIK3CA and TP53 post-zygotic variants in the uninvolved breast tissue of recurrent cancer patients

Maria Andreou, Katarzyna Chojnowska, Natalia H. Filipowicz…·Arkadiusz Piotrowski

The paper identifies pathogenic post-zygotic variants in normal breast tissue of poor-prognosis cancer patients, linking them to reduced survival and disease recurrence.

DOI 10.1101/2024.10.04.24313634

humanwhole-exome sequencing

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Genetic & Genomic MedicineScientific ReportsPeer-reviewedApr 24, 2024

Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases

Magdalena Wójcik, Ulana Juhas, Elyas Mohammadi…·Jan Piotr Dumanski

The paper investigates LOY in TME leukocytes, finding higher LOY frequency in Tregs and its association with immune checkpoint receptor expression.

23 citationstop 4%

humanbulk RNA-seq

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