Arkadiusz Piotrowski

Spatial Transcriptomics of TNBC tumours and corresponding lymph node metastasis reveals immune hubs driven by TNF/NF-κB signalling of TMSB4X and CD74 expressing cells.

The paper uses spatial transcriptomics to identify immune hubs in TNBC lymph node metastases driven by TMSB4X and CD74, revealing spatially expanded inflammatory networks and myeloid-endothelial signaling.

Development of a small-molecule epigenetic regenerative therapy. Subcutaneous administration of alginate formulations with high loads of zebularine and retinoic acid promotes tissue growth, vascularization and innervation and induces extensive epigenetic repatterning

This study develops alginate-based formulations of zebularine and retinoic acid for subcutaneous administration, promoting tissue regeneration and epigenetic changes in mice without adverse effects.

Loss of Y chromosome in Alzheimer disease patients co-occurs with clonal hematopoiesis defined by post-zygotic point mutations outside canonical CHIP driver genes

The paper investigates the relationship between loss of Y chromosome (LOY) and clonal hematopoiesis in Alzheimer's disease patients, finding that LOY drives myeloid clones which may accumulate additional mutations.

The effect of cold ischemia time on hypoxia, EMT, and apoptosis pathways in normal colon mucosa

This study evaluates how cold ischemia time affects gene expression in normal colon mucosa, identifying transcriptomic changes in hypoxia, EMT, and apoptosis pathways that may mimic malignancy.

Beyond Tumors: Reduced survival linked to pathogenic PIK3CA and TP53 post-zygotic variants in the uninvolved breast tissue of recurrent cancer patients

The paper identifies pathogenic post-zygotic variants in normal breast tissue of poor-prognosis cancer patients, linking them to reduced survival and disease recurrence.

Prelude to Malignancy: A Gene Expression Signature in Normal Mammary Gland from Breast Cancer Patients Suggests Pre-tumorous Alterations and Is Associated with Adverse Outcomes

High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing.

Size matters - the impact of nucleus size on results from spatial transcriptomics

This study investigates how nucleus size affects spatial transcriptomics results and introduces CSDI to improve accuracy in analyzing consecutive tissue slices.