Patient-derived lymphocytes drive smoldering lesion pathology in a chimeric multiple sclerosis mouse model
Océane Perrot, Mathias Nordbeck, Corinne Bachelin, A. Luong, Delphine Roussel, David Akbar, Nadège Sarrazin, Arthur Tenenhaus, Céline Louapre, Violetta Zujovic
This study shows that MS patient-derived lymphocytes in a chimeric mouse model drive smoldering lesion pathology, impair functional recovery, and alter CNS cell populations and myelination.
bioRxiv · Sep 16, 2025 · PreprintNeuroscience