Delphine Roussel

Enhancing KCC2 function reduces interictal activity and prevents seizures in mesial temporal lobe epilepsy

This study identifies two compounds that enhance KCC2 function, reducing interictal activity and preventing seizures in mesial temporal lobe epilepsy.

Patient-derived lymphocytes drive smoldering lesion pathology in a chimeric multiple sclerosis mouse model

This study shows that MS patient-derived lymphocytes in a chimeric mouse model drive smoldering lesion pathology, impair functional recovery, and alter CNS cell populations and myelination.

Multiple sclerosis iPSC-derived oligodendroglia conserve their intrinsic properties to functionally interact with axons and glia in vivo

The paper shows MS-derived oligodendroglia can myelinate axons and form functional connections in a mouse model, suggesting the differentiation block is due to environmental factors, not intrinsic deficits.