Anne Eichmann

This study identifies gene-specific mechanisms of AVM formation in endothelial cells with SMAD4 or ALK1 loss-of-function, showing distinct molecular and cellular pathways leading to different vascular malformations.

This study identifies macropinocytosis as the mechanism by which PAI1 is internalized by endothelial cells, allowing it to evade degradation and inhibit eNOS.

This study identifies the nuclear-cytoskeletal interface as a vulnerability in aging endothelium, showing that Progerin disrupts this interface and impairs angiogenesis and lumen formation.

The paper shows that activating RIG-I in macrophages enhances immunotherapy for glioblastoma by repolarizing tumor-associated macrophages and boosting anti-tumor immune responses.

This study investigates the role of endothelial Rho kinase (ROCK1/2) in vascular integrity and angiogenesis, finding that their loss leads to vascular defects and lethality.

This study shows that Netrin-1 overexpression restores blood-retina barrier integrity in retinal diseases by reinforcing barrier stability through the Netrin-1/Unc5b signaling pathway.

The paper identifies PIEZO1 overexpression in HHT2 AVMs and shows that inhibiting PIEZO1 reduces AVM formation in Alk1-deficient mice.

This paper identifies Latrophilin-2 as a mediator of flow-induced Smad1/5 activation in endothelial cells through interactions with Endoglin and Shank3, independent of G-proteins.

This study shows that dural venous stenoses impair lymphatic drainage and brain fluid clearance, and that restoring venous flow can improve clearance in a mouse model.

This study shows that early exposure to a Western diet in female mice leads to severe retinal and neurovascular issues, including anophthalmia and cataracts, highlighting the need for early intervention.

This study identifies the Shroom3 ASD2-domain as critical for profibrotic function in CKD through ROCK activation, showing motif-specific roles in renal fibrosis and albuminuria.

This study shows that VEGF-C overexpression enhances brain fluid drainage, provides neuroprotection, and improves stroke outcomes in mice.

This study shows that Cx43-mediated interactions between neural stem cells and endothelial cells in the SVZ regulate NSC quiescence and neurogenesis.

The paper establishes the 3D anatomy of meningeal lymphatic vasculature and CSF drainage in mice and humans using imaging techniques, showing conserved lymphatic structures.

The paper shows that competition between biochemical and mechanical cues regulates endothelial cell polarity, driving vascular morphogenesis through tension shifts.