ADAR1p150 RNA binding, independent of A-to-I RNA editing, buffers immunogenicity from the tonic type I IFN induced transcriptome in vivo.
Jacki E. Heraud-Farlow, Scott Taylor, Ankita Goradia, Alistair Morgan Chalk, Paul Francis Harrison, Zhen Liang, Monique F. M. A. Smeets, David J. Izon, Shi-Bin Hu, Jin Billy Li, Louise E. Purton, Carl R. Walkley
This study shows ADAR1p150 suppresses immunogenicity from tonic type I IFN-induced transcripts through editing-dependent and -independent mechanisms.
bioRxiv · Oct 14, 2025 · PreprintImmunology