Jacki E. Heraud-Farlow

ADAR1p150 RNA binding, independent of A-to-I RNA editing, buffers immunogenicity from the tonic type I IFN induced transcriptome in vivo.

This study shows ADAR1p150 suppresses immunogenicity from tonic type I IFN-induced transcripts through editing-dependent and -independent mechanisms.

ADAR1p150 Prevents MDA5 and PKR Activation via Distinct Mechanisms to Avert Fatal Autoinflammation

The paper shows that ADAR1p150 prevents MDA5 and PKR activation through distinct mechanisms, preventing fatal autoinflammation.

Generation of a new Adar1p150-/- mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis.

This paper generates and characterizes a new Adar1p150-/- mouse model, showing its essential role in embryonic development and adult homeostasis through IFN response suppression.

The most common human ADAR1p150 Zα domain mutation P193A is well tolerated in mice.

The paper reports that the common ADAR1p150 mutation P193A is well tolerated in mice, with reduced severity when combined with MDA5 loss.