Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress
Anja Karlstaedt, Heidi Vitrac, Rebecca Salazar, Benjamin D. Gould, Daniel Soedkamp, Weston R. Spivia, Koen Raedschelders, An Q Dinh, Anna G. Guzman, Lin Tan, Stavros Azinas, David J.R. Taylor, Walter B. Schiffer, Daniel McNavish, Helen B. Burks, , Heinrich Taegtmeyer
This study shows that D2-HG induces cachexia in mice by disrupting NAD+ homeostasis and autophagy, revealing metabolic vulnerabilities in skeletal muscle.
bioRxiv · Oct 13, 2020 · PreprintSystems Biology