Martina Ulrike Muckenthaler

This study shows that liver sinusoidal endothelial cells (LSECs) integrate metabolic and immune signals through the MAPK pathway to regulate BMP6 and induce hepcidin, maintaining iron homeostasis during inflammation and stress.

The paper shows that activating the NRF2 pathway can safely increase the dose of TXNRD1 inhibitors in SCLC treatment without harming healthy tissues.

This study identifies GLRX3 as a vulnerability in Ewing sarcoma driven by EWSR1::FLI1 fusion oncoproteins, showing its role in oxidative stress and iron homeostasis and potential therapeutic targeting.