Axel Abelein

Opposing Regulation of Tau Condensation by Phosphorylation Levels and Molecular Chaperone Interactions

This study investigates how phosphorylation levels and the molecular chaperone Bri2 BRICHOS opposingly regulate Tau condensation and aggregation, revealing their roles in tauopathies.

Two functionally distinct amyloid-β intermediates link aggregation pathways to pathology in Alzheimer's disease

This study identifies two distinct amyloid-β intermediates that drive Alzheimer's pathology and shows their suppression reduces plaque burden and improves cognition in mice.

Single-molecule mass measurements uncover shifting RNA interactions during condensate phase transitions

The paper uses mass photometry to study RNA-protein interactions in phase-separated systems, showing RNA promotes tau multimerization and phase re-entry.

Liquid-liquid phase separation of tau regulates client binding via a conformational relay

The paper investigates how tau's liquid-liquid phase separation affects its binding to BRICHOS and tubulin, showing conformational changes regulate these interactions.

Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson's Disease

This study identifies secondary nucleation of α-Synuclein as the key mechanism driving mitochondrial dysfunction and Lewy body formation in Parkinson's Disease.