SMAD4 loss drives chromosomal instability during tumourigenesis via translational reprogramming
Julia V. Milne, Kameng Wu, Eric P. Kusnadi, Sandra Brosda, Kenji Mark Fujihara, Ebtihal H Mustafa, Sasha Witts, Katherine Papastratos, Maree Pechlivanis, Anna Trigos, Metta K. Jana, Paul J. McMillan, Thomas Daniel Jackson, Niko Thio, Yuzhou Feng, , Nicholas James Clemons
This study shows SMAD4 loss reprograms translation to induce chromosomal instability, driving tumourigenesis, and identifies CDK11B-p58 as a key mediator.
bioRxiv · Mar 25, 2026 · PreprintCancer Biology